Plenary Session 5207

Parkinson's Disease Fluid and Tissue Biomarkers and Biological Frameworks

Thursday, October 8, 2026
8:00 - 9:30 | Grand Ballroom, Level 1

This plenary will highlight recent advances in Parkinson’s disease fluid and tissue biomarkers, spanning alpha-synuclein–based assays, proteomics, and emerging tissue-based approaches. The speakers will also discuss the biological frameworks that have been derived from recent biomarker advances and critically evaluate their current and future utility in research, diagnosis, and clinical monitoring. The session aims to help clinicians and researchers understand both the promise and limitations of biomarkers across the translational spectrum.

Chairs:

Gabor Kovacs, Canada
Martin McKeown, Canada

Presenters:

Fluid Biomarkers: Alpha-Synuclein and Beyond
Taku Hatano, Japan

Progress on Tissue Biomarkers for Parkinson’s Disease
David Coughlin, USA

Utility of Emerging Parkinson's Disease Biomarkers in Research and Clinical Practice
Claudia Trenkwalder, Germany

CSPC Liaison(s):

Andrew Siderowf, USA

Learning Objectives

At the conclusion of this session, participants should be better able to:

1. Interpret emerging data on fluid biomarkers such as quantitative seed amplification, proteomics and protein biomarkers
2. Describe progress in tissue biomarkers for Parkinson’s disease
3. Recognize the uses and limitations of biomarkers for diagnosis and monitoring and their different roles in research and clinical care

Recommended Audience

Clinician / General Neurology
Fellow / Resident / Student
Health Professional (non-physician)
Industry

Education Level

Intermediate / Experienced