Parallel Session 3407

The Role of a-synuclein and Other Proteins in Parkinson’s Disease Pathogenesis

Tuesday, October 7, 2025
16:30 - 18:00 | Meeting Room 314

In this session, the faculty will discuss the molecular pathomechanisms and the spectrum of proteins involved in Parkinson’s disease, as well as the implications for clinical trials.

Chairs:

Gabor Kovacs, Canada
Per Svenningsson, Sweden

Presenters:

A-Synuclein Prion Strains in Parkinson's Disease Pathogenesis, Phenotype, and Progression
Ayami Okuzumi, Japan

Proteins Beyond A-synuclein: Bystanders or Real Partners?
Zane Jaunmuktane, United Kingdom

Clinical Implications of Co-pathologies
Bradley Boeve, USA

CSPC Liaisons:

Gabor Kovacs, Canada

Learning Objectives

At the conclusion of this session, participants should be better able to:

1. Interpret the role of a-synuclein prion strains in the pathogenesis, phenotypic spectrum and disease progression in Parkinson’s disease
2. Recognize the spectrum of proteins involved beyond a-synuclein in the pathogenesis of Parkinson’s disease
3. Interpret the relevance of mixed pathologies in patient selection and clinical trial design

Recommended Audience

Clinician / General Neurology
Fellow / Resident / Student
Industry
Researcher / Basic Science

Education Level

Advanced / Expert
Intermediate / Experienced

Focus

Basic Science
Translational